| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365049 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A series of fatty acid monoester derivatives of (−)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG.
Graphical abstractA series of fatty acid monoester derivatives of (−)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity up to 24-fold relative to native EGCG.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Shuichi Mori, Shinya Miyake, Takayoshi Kobe, Takaaki Nakaya, Stephen D. Fuller, Nobuo Kato, Kunihiro Kaihatsu,