| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365167 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
We have developed a new fluorescent probe for biological thiol. The probe was synthesized by the modification of the 2,4-dinitrobenzenesulfonyl group with rhodamine 110. The selective detection of thiol species such as cysteine or glutathione was achieved in biological conditions. Moreover, the probe was successfully applied to the imaging of thiol species in living human cells.
Graphical abstractFluorogenic probe for the detection of intracellular thiols.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aya Shibata, Kazuhiro Furukawa, Hiroshi Abe, Satoshi Tsuneda, Yoshihiro Ito,