Article ID Journal Published Year Pages File Type
1365170 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract

N-(14-Methylallyl)norgalanthamine, a new natural compound, together with five known alkaloids: N-allylnorgalanthamine, galanthamine, epinorgalanthamine, narwedine, and lycorine were isolated from mother liquors (waste material) obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves. The structures of N-allylnorgalanthamine and N-(14-methylallyl)norgalanthamine were completely determined by 1H and 13C NMR spectroscopy and two-dimensional experiments. N-allylnorgalanthamine (IC50 = 0.18 μM) and N-(14-methylallyl)norgalanthamine (IC50 = 0.16 μM) inhibit AChE considerably more than the approved drug galanthamine (IC50 = 1.82 μM).

Graphical abstractN-Allylnorgalanthamine (1) and N-(14-methylallyl)norgalanthamine (2) inhibit AChE more than the approved drug galanthamine.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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