Article ID Journal Published Year Pages File Type
1365180 Bioorganic & Medicinal Chemistry Letters 2008 5 Pages PDF
Abstract

The synthesis and structure–activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this previously disclosed core afforded compounds with improved enzymatic and cellular potency.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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