Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365183 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Also described are the detailed SAR study and the BaF3 cell line profiling for this series.
Graphical abstractA novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Many potent analogues were generated with urea, carbamate, heteroarylamine or alkylamine at the C-2 position. The SAR for the middle ring and the right side aryl group was also explored. The selectivity profile was herein included.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shenlin Huang, Zuosheng Liu, Shin-Shay Tian, Mark Sandberg, Tracy A. Spalding, Russell Romeo, Maya Iskandar, Zhiliang Wang, Donald Karanewsky, Yun He,