| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365193 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.
Graphical abstractThe syntheses of a new class of barbiturate-based inhibitors for methionine aminopeptidase-1 are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manas K. Haldar, Michael D. Scott, Nitesh Sule, D.K. Srivastava, Sanku Mallik,