| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365194 | Bioorganic & Medicinal Chemistry Letters | 2008 | 8 Pages |
Oligodeoxynucleic acid (21-mer) containing both negatively charged phosphate and positively charged ribonucleic guanidine linkages (RNG/DNA chimera) have been synthesized. DNA binding characteristics and nuclease resistance of RNG/DNA chimeras have been evaluated. Using the bcr-abl oncogene (cause of chronic myeloid leukemia) as a target, the binding of a 21-mer RNG/DNA chimera that includes six RNG’s is more than 103.5 stronger than the binding of 21-mer composed solely of DNA.
Graphical abstractOligodeoxynucleic acid (21-mer) containing both negatively charged phosphate and positively charged ribonucleic guanidine linkages (RNG/DNA chimera) have been synthesized. Binding properties and nuclease resistance against exonuclease I of RNG/DNA chimera are presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
