| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365201 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
Modification of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martin E. Hayes, Eric C. Breinlinger, Grier A. Wallace, Pintipa Grongsaard, Wenyan Miao, Michael J. McPherson, Robert H. Stoffel, David W. Green, Gregory P. Roth,