| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365202 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A number of sterically-hindered o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered free-radical intermediates was investigated. Of the compounds tested, the highest activity in suppressing replication of Herpes simplex type l viruses was displayed by N-acyl and N-aryl derivatives of 4,6-di-tert-butyl-2-aminophenol, which were able to interact with organic free radicals and, at the same time, manifested low reactivity towards reactive oxygen species.
Graphical abstractIt has been shown that N-acyl and N-aryl derivatives of 4,4-di-tert-butyl-2-aminophenol passes the most marked antiviral activity.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
O. Shadyro, G. Ksendzova, G. Polozov, V. Sorokin, E. Boreko, O. Savinova, B. Dubovik, N. Bizunok,