| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365210 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The reaction of triptolide and its analogues with a fluorinating agent, that is, bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor) or (diethylamino)sulfur trifluoride (DAST), was studied. One of the fluorinated products, 14β-dehydroxy-14β-fluoro triptolide, was found to be more cytotoxic than the parent natural triptolide.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yutaka Aoyagi, Yukio Hitotsuyanagi, Tomoyo Hasuda, Saki Matsuyama, Haruhiko Fukaya, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki, Shusuke Hashimoto,