| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365219 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.
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Related Topics
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Organic Chemistry
Authors
Hyun-Soon Chong, Hyun A. Song, Sooyoun Lim, Keith Macrenaris, Xiang Ma, Haisung Lee, Phuong Bui, Thomas Meade,