| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365351 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
T-type calcium channel antagonists were designed using a protocol involving the program SPROUT and constrained by a ComFA-based pharmacophore model. Scaffolds generated by SPROUT were evaluated based on their ability to be translated into structures that were synthetically tractable. From this exercise, a novel series of potent and selective T-type channel antagonists containing a biaryl sulfonamide core were discovered.
Graphical abstractT-type calcium channel antagonists were designed using a protocol involving the program SPROUT constrained by a ComFA-based pharmacophore model. From this exercise, a novel series of potent and selective T-type channel antagonists containing a biaryl sulfonamide core were discovered.Figure optionsDownload full-size imageDownload as PowerPoint slide
