| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365360 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.
Graphical abstractA series of simple synthetic flavonoid derivatives were found to have significant antifungal activity. Two of the compounds also displayed antibacterial activity against methicillin-resistant Staphylococcus aureus.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sherif B. Abdel Ghani, Louise Weaver, Zidan H. Zidan, Hussein M. Ali, C. William Keevil, Richard C.D. Brown,