| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365364 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series (5) and benzoic acid series (6), designed by exploring the molecular hybridization approach between isoniazid (1) and trans-cinnamic acid derivative (3). The minimum inhibitory concentration (MIC) of the compounds 5a–d and 6c exhibited activity between 3.12 and 12.5 μg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.
Graphical abstractThe present article describes a series of ten new trans-cinnamic acid hydrazide derivatives, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis.Figure optionsDownload full-size imageDownload as PowerPoint slide
