Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365378 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Two stereoselective parallel divergent four-step procedures to obtain all four enantiomeric forms of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide were developed. Enantiomeric purity was determined by quantitative 1H NMR spectroscopy in the presence of the chiral shift reagent (+)-MTPA. The biological profile of the obtained compounds was evaluated at all muscarinic receptor subtypes by binding and functional assays.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alessandro Piergentili, Wilma Quaglia, Mario Giannella, Fabio Del Bello, Michela Buccioni, Marta Nesi, Rosanna Matucci,