| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365393 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
The design and synthesis of a novel class of human bradykinin B1 antagonists featuring difluoroethyl ether and isoxazole carboxamide moieties are disclosed. Compound 7g displayed excellent pharmacokinetic properties, efficient ex vivo receptor occupancy, and low potential for P450 induction via PXR activation.
Graphical abstractThe design and synthesis of a novel class of human bradykinin B1 antagonists featuring difluoroethyl ether and isoxazole carboxamide moieties are disclosed.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dong-Mei Feng, Robert M. DiPardo, Jenny M. Wai, Ronald K. Chang, Christina N. Di Marco, Kathy L. Murphy, Richard W. Ransom, Duane R. Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone, Mark G. Bock, Scott D. Kuduk,