Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365398 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARα agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported.
Graphical abstractStarting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARα agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound 20 are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Nicolas Faucher, Paul Martres, Alain Laroze, Olivier Pineau, Florent Potvain, Didier Grillot,