Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365402 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor. Modifications of the P1 benzyl moiety led to improvements in ACE2 potency as well as to increased selectivity versus ACE and NEP.
Graphical abstractScreening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor. Modifications of the P1 benzyl moiety led to improvements in ACE2 potency as well as to increased selectivity versus ACE and NEP.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David N. Deaton, Enoch N. Gao, Kevin P. Graham, Jeffrey W. Gross, Aaron B. Miller, John M. Strelow,