| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365406 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
In our effort to find potent, orally bioavailable CGRP receptor antagonists for the treatment of migraine, a novel series based on a pyridinone template was investigated. After optimizing the privileged structure and the placement of the attached phenyl ring, systematic SAR was carried out on both the N-alkyl and C-5 aryl substituents. Several analogs with good potency and pharmacokinetic profiles were identified.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Diem N. Nguyen, Daniel V. Paone, Anthony W. Shaw, Christopher S. Burgey, Scott D. Mosser, Victor Johnston, Christopher A. Salvatore, Yvonne M. Leonard, Cynthia M. Miller-Stein, Stefanie A. Kane, Kenneth S. Koblan, Joseph P. Vacca, Samuel L. Graham,