| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365408 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Honglu Zhang, Yong Xu, Nicolas Markadieu, Renaud Beauwens, Christophe Erneux, Glenn D. Prestwich,