Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365414 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A set of regioisomeric 2-substituted pyridazin-3(2H)-ones containing a 3-oxo-3-phenylprop-1-en-1-yl fragment at either position 4, 5 or 6 and 2-substituted pyridazin-3(2H)-ones containing the same fragment both at positions 4 and 5 have been synthesized and evaluated as antiplatelet agents. The study allows the identification of a new highly potent platelet aggregation inhibitor (4c).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Caroline Meyers, Matilde Yáñez, Abdelaziz Elmaatougi, Tom Verhelst, Alberto Coelho, Nuria Fraiz, Guy L.F. Lemière, Xerardo Garcı´a-Mera, Reyes Laguna, Ernesto Cano, Bert U.W. Maes, Eddy Sotelo,