New polyphenols active on β-amyloid aggregation

New polyphenol classes have been tested against amyloid-β peptide aggregation. We have identified four novel polyphenols which could be efficient fibril inhibitors in Alzheimer’s disease: malvidin and its glucoside and curculigosides B and D. We suggest that molecules with the particular C6-linkers-C6 structure could be potent inhibitors. From the results reported for the flavan-3-ol family, their anti-amyloidogenic effects against whole peptides (1–40 and 1–42) could involve several binding sites.

Graphical abstractFour novel polyphenols could be efficient fibril inhibitors in Alzheimer’s disease: malvidin and its glucoside and curculigosides B and D. Moreover, molecules with the particular C6-linkers-C6 structure could be potent inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide