| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365423 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The synthesis and initial evaluation of novel chromogenic substrates with potential in the detection and differentiation of cultured bacterial colonies are described. The substrates were readily hydrolysed by specific aminopeptidase activity to release the chromogen, 9-(4′-aminophenyl)-10-methylacridinium salt, which provided a clear visual indication of the presence of the corresponding bacteria.
Graphical abstractThe synthesis and evaluation of novel chromogenic peptidase substrates 4a–g with good species specificity are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rosaleen J. Anderson, Paul W. Groundwater, Yongxue Huang, Arthur L. James, Sylvain Orenga, Annette Rigby, Céline Roger-Dalbert, John D. Perry,