| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365502 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC50 = 41 ± 1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Han Na Seo, Ja Youn Choi, Yun Jeong Choe, Yoonjee Kim, Hyewhon Rhim, So Ha Lee, Jungahn Kim, Dong Jun Joo, Jae Yeol Lee,