Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365506 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Four small molecular receptors of vancomycin have been designed to make part of a novel biosensor device based on the FTIR-ATR detection: N-Boc (2a) or N-Ac (2b)-6-aminocaproyl-d-Ala-d-Ala and N-Boc (3a) or N-Ac (3b)-6-aminocaproyl-d-Ala-d-Ser. Using an original microbiological approach to assess the competition of compounds with the natural target of vancomycin in bacteria, EC50 values of 6.3–8.0 × 10−5 M (2a–b) and 7.1–9.3 × 10−4 M (3a–b) were determined. Vancomycin:2b complex was characterized by MS.
Graphical abstractUse of an original microbiological approach to assess competition of synthetic compounds with the natural target of vancomycin in bacteria.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Olivier Hernout, Karine Berthoin, Isabelle Delattre, Paul M. Tulkens, Stéphane Carryn, Jacqueline Marchand-Brynaert,