Article ID Journal Published Year Pages File Type
1365507 Bioorganic & Medicinal Chemistry Letters 2007 5 Pages PDF
Abstract

11-Hydroxyindeno[1,2-c]isoquinolines 12a–c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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