| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365508 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
3-[4â²-H-Dmt-NH-(CH2)4]-6-β-phenethyl-5-methyl-2(1H)-pyrazinone 11 bound to μ-opioid receptors, Kiμ = 0.13 nM and Kiδ/Kiμ = 447, and exhibited μ-agonism (GPI IC50 = 15.9 nM) and δ-antagonism (MVD, pA2 = 6.35).
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kimitaka Shiotani, Tingyou Li, Anna Miyazaki, Yuko Tsuda, Toshio Yokoi, Akihiro Ambo, Yusuke Sasaki, Sharon D. Bryant, Lawrence H. Lazarus, Yoshio Okada,