| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365509 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
We synthesized a novel peptide-resin conjugate by immobilizing β-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism with vancomycin. Specially, the peptide-resin conjugate showed a more increased lipid membrane perturbation activity in comparison to unbound β-sheet antibacterial peptide.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Won-Mi Cho, Bishnu Prasad Joshi, Hyeongjin Cho, Keun-Hyeung Lee,