| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365510 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
The synthesis and biological evaluation of corosolic acid derivatives and related compounds as inhibitors of rabbit muscle glycogen phosphorylase a is described. Within this series of compounds, 8 (IC50 = 7.31 μM), 12d (IC50 = 3.26 μM), and 12e (IC50 = 5.1 μM) exhibited more potent activities than the parent compound 1 (IC50 = 20 μM). SAR of these compounds is also discussed.
Graphical abstractThe synthesis and biological evaluation of corosolic acid derivatives as inhibitors of glycogen phosphorylase is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Xiaoan Wen, Jun Xia, Keguang Cheng, Liying Zhang, Pu Zhang, Jun Liu, Luyong Zhang, Peizhou Ni, Hongbin Sun,