| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365518 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33.
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Related Topics
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Organic Chemistry
Authors
Vijay K. Gore, Vu V. Ma, Rami Tamir, Narender R. Gavva, James J.S. Treanor, Mark H. Norman,