| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365522 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC50 values as low as 5.8 nM for inhibition of DPP-4.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ping Chen, Charles G. Caldwell, Robert J. Mathvink, Barbara Leiting, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry, Ann E. Weber,