Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365540 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and commercially available 3-carboxylic acid thioxanthen-9-one-10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alkaline phosphatase reported replicon system for activity against hepatitis C virus.
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Authors
Pedro M.J. Lory, Maria E. Estrella-Jimenez, Matthew J. Shashack, Ganesh L. Lokesh, Amarnath Natarajan, Scott R. Gilbertson,