| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365547 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Synthesis and structure–activity relationship of a series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitrile derivatives as EGFR inhibitors is described. Compounds 29 and 30 showed potent in vitro inhibitory activity in the enzymatic assay as well as in the functional cellular assay. They are moderately selective against other types of tyrosine kinases.
Graphical abstractA series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles have been synthesized and tested for EGFR inhibition. Compounds 29 and 30 showed excellent enzymatic and cellular activities against EGFR.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Madhavi Pannala, Sunil Kher, Norma Wilson, John Gaudette, Ila Sircar, Shao-Hui Zhang, Alexei Bakhirev, Guang Yang, Phoebe Yuen, Frank Gorcsan, Naoki Sakurai, Miguel Barbosa, Jie-Fei Cheng,