| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365548 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.
Graphical abstractThe synthesis, pharmacology, and pharmacokinetic profiles of (1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This agent demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lain-Yen Hu, Daniel Du, Jennifer Hoffman, Yvonne Smith, Victor Fedij, Catherine Kostlan, Theodore R. Johnson, Yun Huang, Steve Kesten, William Harter, Wen Song Yue, Jie Jack Li, Nicole Barvian, Lorna Mitchell, Huangshu John Lei, Bruce Lefker,