Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365556 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Cyclic PNAs targeting the HIV-1 TAR RNA loop have been synthesized following a convenient solid-phase strategy which allows on-resin cyclisation. UV-monitored thermal denaturation studies demonstrate that these cyclic PNAs are able to strongly interact with their TAR RNA target, very likely through the formation of a six-base pair stable complex, involving the TAR RNA loop.
Graphical abstractThe solid-phase synthesis of cyclic PNA-based compounds and their binding to the HIV-1 TAR RNA fragment is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gregory Upert, Mohamed Mehiri, Audrey Di Giorgio, Roger Condom, Nadia Patino,