| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365686 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
In an effort to understand the effect of N-alkylation of triarylimidazoles on Tie2 inhibition, ortho-substituted C-2 aryl analogs were synthesized to investigate the effect of different torsion angles on potency. This exercise resulted in the identification of a potent and selective tetrasubstituted imidazole that was efficacious in an animal model of angiogenesis.
Graphical abstractOptimization of triarylimidazoles for Tie2 potency resulted in the identification of the potent and selective tetrasubstituted imidazole 23 that was efficacious in an animal model of angiogenesis.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Neil W. Johnson, Marcus Semones, Jerry L. Adams, Michael Hansbury, Jim Winkler,