| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365687 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
The thiazole-diamide series (1) has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC50 values of <0.3 nM. The synthesis and SAR, as well as a radiolabeled synthesis of [3H]-2a, are described.
Graphical abstractThe thiazole-diamide series has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC50 values of <0.3 nM. The synthesis and SAR, as well as [3H]-2a, are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Yuhpyng L. Chen, Kevin Cherry, Michael L. Corman, Charles F. Ebbinghaus, Chandra B. Gamlath, Dane Liston, Barbara-Anne Martin, Christine E. Oborski, Barbara G. Sahagan,