| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365692 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A novel potent NMDA-NR2B selective antagonist (5b) without the reactive metabolites formation issue was identified. Through this study, a close correlation between reactive metabolites formation and calculated HOMO energies of parent compounds was found.
Graphical abstractReplacement of the phenol moiety with pyrazole led to a novel potent NMDA-NR2B selective antagonist (5b) with an improved metabolic profile. Through this study, a close correlation between reactive metabolites formation and calculated HOMO energies of parent compounds was found.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Makoto Kawai, Isao Sakurada, Asato Morita, Yuko Iwamuro, Kazuo Ando, Hirofumi Omura, Sachiko Sakakibara, Tsutomu Masuda, Hiroki Koike, Teruki Honma, Kazunari Hattori, Tadayuki Takashima, Kunihiko Mizuno, Mayumi Mizutani, Mitsuhiro Kawamura,