| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365705 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Analogues of pindolol, 1-(1H-indol-4-yloxy)-3-isopropylamino-propan-2-ol, were synthesized and evaluated as 5-HT1A receptor antagonists. The structural features required for optimal binding to the 5-HT1A receptor are as follows: S-2-propanol linker, 4-indoloxy substituent, and a large lipophilic cyclic amine substituent.
Graphical abstractThe discovery and synthesis of the 5-HT1A receptor antagonist 13a is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joseph H. Krushinski Jr., John M. Schaus, Dennis C. Thompson, David O. Calligaro, David L. Nelson, Susan H. Luecke, David B. Wainscott, David T. Wong,