Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365723 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A hydroxy functional group was introduced as the hydrogen bond donor and acceptor at the hinge region of protein kinase in order to develop novel ATP-competitive inhibitors. Several derivatives of 7-hydroxyl-1H-benzoimidazole were designed as inhibitors of glycogen synthase kinase-3β with the help of ab initio calculations and a docking study. Enzymatic assay and an X-ray complex study showed that these designed compounds were highly potent ATP-competitive inhibitors.
Graphical abstractWe have designed new kinase inhibitors by considering the hydrogen bond network in the hinge region and confirmed through the enzymatic assay and X-ray crystallography.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dongkyu Shin, Seung-Chul Lee, Yong-Seok Heo, Woon-Young Lee, Yong-Soon Cho, Yong Eun Kim, Young-Lan Hyun, Joong Myung Cho, Yoon Sup Lee, Seonggu Ro,