| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365726 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
ESR spin trapping allows detection of superoxide radicals. Novel spin traps forming more stable superoxide adducts (t1/2 ca. 12–55 min) were tested for their toxicity to cultured cells. The following toxicity ranking was obtained: 4,5-DPPO > 4-BEMPO ∼ 3-BEMPO > trans-3,5-EDPO > 3,5-DPPO ∼ 4,5-DiPPO ∼ 4,5-EDPO > cis-3,5-EDPO ∼ 3,5-DiPPO > DEPMPO. In conclusion, 4,5-EDPO, cis-3,5-EDPO and 3,5-DiPPO can be recommended for further investigation of superoxide in biological systems.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nataliya Rohr-Udilova, Klaus Stolze, Sandra Sagmeister, Wolfram Parzefall, Brigitte Marian, Hans Nohl, Rolf Schulte-Hermann, Bettina Grasl-Kraupp,