Melanocortin subtype 4 receptor agonists: Structure–activity relationships about the 4-alkyl piperidine core

SAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported.

Graphical abstractSAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide