| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365867 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC50 = 12 μM.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claudia Mugnaini, Suvi Rajamaki, Cristina Tintori, Federico Corelli, Silvio Massa, Myriam Witvrouw, Zeger Debyser, Veljko Veljkovic, Maurizio Botta,