| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365875 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A new cyclic heptapeptide, cyclonatsudamine A (1), cyclo (-Gly-Tyr-Leu-Leu-Pro-Pro-Ser-), has been isolated from the peels of Citrus natsudaidai and the structure was elucidated by 2D NMR analysis and chemical degradation. Cyclonatsudamine A (1) relaxed norepinephrine-induced contractions of rat aorta, which may be mediated through the increased release of NO from endothelial cells.
Graphical abstractA new cyclic heptapeptide, cyclonatsudamine A (1), has been isolated from the peels of Citrus natsudaidai and the structure was elucidated by 2D NMR analysis and chemical degradation. Cyclonatsudamine A relaxed norepinephrine-induced contractions of rat aorta.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroshi Morita, Maiko Enomoto, Yusuke Hirasawa, Toru Iizuka, Kazunori Ogawa, Nobuo Kawahara, Yukihiro Goda, Teruki Matsumoto, Koichi Takeya,