| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365878 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
Graphical abstractCinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized. The compounds inhibited the growth of human tumor cells through induction of apoptosis and arresting cell cycle at G2/M phase.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dae-Seop Shin, Jiin Kim, Dong Cho Han, Kwang-Hee Son, Chang Woo Lee, Hwan-Mook Kim, Su Hyung Hong, Byoung-Mog Kwon,