| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365880 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.
Graphical abstractHIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Subharekha Raghavan, Zhijian Lu, Teresa Beeson, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Lori Gabryelski, Emilio Emini, James R. Tata,