| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365886 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
Abstract
A new series of FTase inhibitors containing a tricyclic moiety—dioxodibenzothiazepine or dibenzocycloheptane—has been designed and synthesized. Among them, dioxodibenzothiazepine 18d displayed significant inhibitory FTase activity (IC50 = 17.3 nM) and antiproliferative properties.
Graphical abstractThe design, synthesis, inhibitory FTase activity and antiproliferative properties of the title tricyclic compounds are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pauline Gilleron, Nicolas Wlodarczyk, Raymond Houssin, Amaury Farce, Guillaume Laconde, Jean-François Goossens, Amélie Lemoine, Nicole Pommery, Jean-Pierre Hénichart, Régis Millet,