| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365887 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
Abstract
Following our previous publication describing the biological profiles, we herein describe the structure–activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.
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Authors
Min Teng, Michael D. Johnson, Christine Thomas, Dan Kiel, James N. Lakis, Tim Kercher, Shelley Aytes, Jarek Kostrowicki, Dilip Bhumralkar, Larry Truesdale, John May, Ulla Sidelman, Janos T. Kodra, Anker Steen Jørgensen, Preben Houlberg Olesen,