| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366052 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
We have developed a new class of N-methyl-d-aspartate (NMDA) channel blockers having a conjugate structure that consists of a nitrogenous heterocyclic head and a tetraamine tail. Among them, dihydrodibenzazepine-homospermine conjugate (8) exhibited potent antagonistic activity at NR1/NR2A or NR1/NR2B NMDA subtype receptors compared with the lead compound, AQ343 (1), or memantine, as well as weak cytotoxicity. Its superior biological profiles compared with known compounds point to its potential use as therapeutic agents for neurological disorders.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiromitsu Takayama, Yuichi Yaegashi, Mariko Kitajima, Xia Han, Kazuhiro Nishimura, Shigeru Okuyama, Kazuei Igarashi,