| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366059 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor γ (PPARγ).
Graphical abstractMycophenolic acid (1), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of 1 could be attributed to inhibition of IMPDH, we identified 1 as a latent agonist of PPARγ. This is the first report that molecular target of 1 except IMPDH was found.Figure optionsDownload full-size imageDownload as PowerPoint slide
